Results from combining both NMN and NR for enhanced NAD+ elevation?

2026-06-22T10:37:56Z

Hi folks, I've been experimenting with both nicotinamide mononucleotide and nicotinamide riboside combined for the past several weeks and surprisingly the results on my overall vitality have been remarkable - from what I understand taking the combination works better than either one by itself because they take separate routes for NAD+ biosynthesis, with NR going through the NRK1 NRK2 enzymes while NMN uses the Slc12a8 transporter, and since NAD+ levels decline with age this combined strategy really helps increase NAD+ effectively for better mitochondrial support compounds (scholarlyresources.digitalscholarship.brown.edu) function - I'm currently taking moderate doses of both in the early hours with some TMG for methylation support and my sleep quality have gotten much better, though I'm wondering if whether folks here

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Results from combining both NMN and NR for enhanced NAD+ elevation?