Results from combining both NMN and NR for enhanced NAD+ boost?

null@example.com (KathyClafl) — Tue, 23 Jun 2026 06:55:51 +0000

Been experimenting with stacking NMN and NR together for the past year and honestly the dual approach on my NAD+ levels has been remarkable - I take 1000mg of each with breakfast and my mitochondrial function feel like they've gone back to my prime years, plus my healthcare provider confirmed my lab results show substantial increases in insulin sensitivity and the pairing seems to work better than either nicotinamide mononucleotide or nicotinamide riboside alone since they utilize separate absorption routes with NMN using the Slc12a8 transporter while NR goes through the Preiss-Handler pathway so you're essentially targeting different mechanisms of NAD+ restoration which is vital for SIRT1 function, DNA repair, and reversing the natural NAD+ decline with age that starts around 40 - definitely recommend adding apigenin as a CD38 enzyme inhibitor to minimize NAD+ degradation and maybe some TMG for methyl donor function.

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Results from combining both NMN and NR for enhanced NAD+ boost?